(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Base Information

Chemical Name:(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
CAS No.:1386935-73-4
Molecular Formula:C₂₅H₂₈ClN₅O₈
Molecular Weight:561.979
Hs Code.:

Synonyms:(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

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Chemical Property of (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

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Technology Process of (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

There total 1 articles about (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3056-18-6
(2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl acetate

: 1795-98-8,3182-95-4,5267-64-1,16088-07-6
rac-phenylalaninol

: 1386935-73-4
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: With triethylamine; In ethanol; at 70 ℃; for 12h;
DOI:10.1021/jm3004834

Reference yield: 60.0%

: 1386935-73-4
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

: 76-05-1
trifluoroacetic acid

: 1403619-43-1
(2R,3R,4S,5R)-2-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol trifluoroacetic acid salt

Guidance literature:: (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-chloro-6-((1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; With ammonia; In methanol; at 0 - 20 ℃;

trifluoroacetic acid; In methanol; water;
DOI:10.1021/jm3004834