1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

Base Information

Chemical Name:1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide
CAS No.:122223-49-8
Molecular Formula:C₂₇H₂₅FN₂O
Molecular Weight:412.507
Hs Code.:

Synonyms:1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

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Chemical Property of 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

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Technology Process of 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

There total 2 articles about 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 134538-46-8,775-31-5
1-(4-fluorophenyl)-2-nitropropene

: 124401-43-0
(E)-2,4-Dimethyl-3-phenylamino-pent-2-enoic acid phenylamide

: 122223-49-8
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

Guidance literature:: In ethanol; for 12h; Heating;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-49-8
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

Guidance literature:

Reference yield:

: 122223-49-8
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

: 124089-69-6,124401-32-7
methyl 3(RS),5(RS)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrol-3-yl>heptanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

2: 63 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

3: 45 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h / 20 - 24 °C

6: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

7: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

With pyridine; chromium(VI) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00163a011