1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

Base Information

Chemical Name:1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide
CAS No.:122223-50-1
Molecular Formula:C₂₈H₂₇FN₂O
Molecular Weight:426.534
Hs Code.:

Synonyms:1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

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Chemical Property of 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

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Technology Process of 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

There total 1 articles about 1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122223-49-8
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxanilide

: 74-88-4
methyl iodide

: 122223-50-1
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux;
DOI:10.1021/jm00163a011

Reference yield: 63.0%

: 122223-50-1
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

: 122223-51-2
1-phenyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-5-methyl-1H-pyrrole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-50-1
1-phenyl-2-isopropyl-4-(4-fluorophenyl)-5-methyl-N-methyl-1H-pyrrole-3-carboxanilide

: 6-{2-[4-(4-Fluoro-phenyl)-2-isopropyl-5-methyl-1-phenyl-1H-pyrrol-3-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

2: 45 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h / 20 - 24 °C

5: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

6: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

With pyridine; chromium(VI) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00163a011