(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

Base Information

Chemical Name:(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid
CAS No.:634902-48-0
Molecular Formula:C₂₄H₃₂N₄O₄
Molecular Weight:440.542
Hs Code.:

Synonyms:(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

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Chemical Property of (E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

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Technology Process of (E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

There total 5 articles about (E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-tert-butyl-cyclohexyl)-5-methyl-2,4-dihydro-pyrazol-3-one

: C₁₀H₁₁NO₃*ClH

: 634902-48-0
(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

Guidance literature:: C₁₀H₁₁NO₃*ClH; With hydrogenchloride; sodium nitrite; In ethanol; water; at 0 ℃; for 0.25h;

2-(4-tert-butyl-cyclohexyl)-5-methyl-2,4-dihydro-pyrazol-3-one; In ethanol; water; at 20 ℃; for 18h; pH=8; Alkaline conditions;

Reference yield:

: 98-53-3
4-tercbutyl-cyclohexanone

: 634902-48-0
(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 18 h / Presence of drying agents

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 2585.81 Torr

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.1: acetic acid / 18 h / 100 °C

5.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h / 0 °C

5.2: 18 h / 20 °C / pH 8 / Alkaline conditions

With hydrogenchloride; hydrogen; trifluoroacetic acid; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;

Reference yield:

: 60295-14-9
N'-(4-tert-butyl-cyclohexylidene)-hydrazinecarboxylic acid tert-butyl ester

: 634902-48-0
(E)-3-{4-[1-(4-tert-butylcyclohexyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylazo]-3-hydroxyphenyl}-2-methylacrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 h / 2585.81 Torr

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3.1: acetic acid / 18 h / 100 °C

4.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h / 0 °C

4.2: 18 h / 20 °C / pH 8 / Alkaline conditions

With hydrogenchloride; hydrogen; trifluoroacetic acid; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;