(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Base Information

Chemical Name:(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine
CAS No.:326598-69-0
Molecular Formula:C₂₂H₂₁N₃O₅S
Molecular Weight:439.492
Hs Code.:

Synonyms:(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

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Chemical Property of (Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

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Technology Process of (Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

There total 5 articles about (Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 326598-63-4
N-{2-[3-(2,4-dimethoxy-pyrimidin-5-yl)-prop-2-ynyloxy]-phenyl}-4-methyl-benzenesulfonamide

: 326598-69-0
(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: With copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; In acetonitrile; for 12h; Heating;
DOI:10.1021/jo000826j

Reference yield:

: 13350-09-9
1-nitro-2-(prop-2-yn-1-yloxy)benzene

: 326598-69-0
(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 4 steps

1: Fe; AcOH

2: 78 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / 16 h / 20 °C

3: 78 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

4: 71 percent / CuI; K₂CO₃; Bu₄NBr / acetonitrile / 12 h / Heating

With pyridine; copper(l) iodide; tetrabutylammomium bromide; iron; potassium carbonate; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile;
DOI:10.1021/jo000826j

Reference yield:

: 52536-39-7
2-(prop-2-ynyloxy)benzenediazonium tetrafluoroborate

: 326598-69-0
(Z)-3-[(2,4-dimethoxypyrimidin-5-yl)methylidene]-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / 16 h / 20 °C

2: 78 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

3: 71 percent / CuI; K₂CO₃; Bu₄NBr / acetonitrile / 12 h / Heating

With pyridine; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile;
DOI:10.1021/jo000826j