4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

Base Information

Chemical Name:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride
CAS No.:1364613-72-8
Molecular Formula:C₃₉H₄₁Cl₂F₂N₃O₄*ClH
Molecular Weight:761.136
Hs Code.:

4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

Synonyms:4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

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Chemical Property of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

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Technology Process of 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

There total 2 articles about 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

: 1364616-07-8
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid methyl ester

: 1364613-72-8
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

Guidance literature:: 4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid methyl ester; With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride;

Reference yield:

: 1229705-05-8
4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-3-methoxybenzoic acid methyl ester

: 5664-21-1
cyclohexylacetaldehyde

: 1364613-72-8
4-[(3S,5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-3-cyclohexylmethyl-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 50 - 70 °C

2: potassium hydroxide / tetrahydrofuran; methanol / 20 °C

With acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;