difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

Base Information

Chemical Name:difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester
CAS No.:950505-27-8
Molecular Formula:C₂₂H₂₄F₂O₅
Molecular Weight:406.426
Hs Code.:

Synonyms:difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

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Chemical Property of difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

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Technology Process of difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

There total 3 articles about difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 139149-06-7
6-(4-methoxy-benzyloxy)-3,4-dihydro-2H-naphthalen-1-one

: 667-27-6
Ethyl bromodifluoroacetate

: 950505-27-8
difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

Guidance literature:: With iodine; zinc; In tetrahydrofuran; for 3h; Heating / reflux;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 950505-27-8
difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: iodine; zinc / tetrahydrofuran / 3 h / Heating / reflux

With iodine; caesium carbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 950505-27-8
difluoro-[1-hydroxy-6-(4-methoxy-benzyloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: iodine; zinc / tetrahydrofuran / 3 h / Heating / reflux

With iodine; caesium carbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;