(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Base Information

Chemical Name:(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid
CAS No.:1613134-36-3
Molecular Formula:C₂₁H₂₀BF₄N₅O₄
Molecular Weight:493.226
Hs Code.:

Synonyms:(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

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Chemical Property of (R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

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Technology Process of (R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

There total 4 articles about (R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1613134-49-8
1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-2H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0²'⁶]dec-4-yl)ethyl]amide

: 1613134-36-3
(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; hexane; water; at 20 ℃;

Reference yield:

: 115029-24-8
2-fluoro-4-(trifluoromethyl)benzoic acid

: 1613134-36-3
(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; hexane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 1613134-45-4
1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

: 1613134-36-3
(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; water; hexane / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; hexane; water; N,N-dimethyl-formamide;