1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Base Information

• Chemical Name: 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid
• CAS No.: 1613134-47-6
• Molecular Formula: C₁₃H₁₀F₄N₄O₃
• Molecular Weight: 346.241

Synonyms:1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Chemical Property of 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

There total 3 articles about 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1613134-45-4) → 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-47-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

Reference yield:

2-fluoro-4-(trifluoromethyl)benzoic acid (115029-24-8) → 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / methanol / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl acetamide;

Reference yield:

→ 1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid (1613134-47-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

upstream raw materials:

2-fluoro-4-(trifluoromethyl)benzoic acid

1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Downstream raw materials:

1-[2-(2-fluoro-4-trifluoromethylbenzoylamino)ethyl]-2H-[1,2,3]triazole-4-carboxylic acid [(R)-2-phenyl-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0²'⁶]dec-4-yl)ethyl]amide

(R)-1-(1-(2-(2-fluoro-4-(trifluoromethyl)benzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)-2-phenylethylboronic acid

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