Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

Base Information

Chemical Name:Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester
CAS No.:1026042-63-6
Molecular Formula:C₂₃H₃₅BrO₄Si
Molecular Weight:483.518
Hs Code.:

Synonyms:Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

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Chemical Property of Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

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Technology Process of Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

There total 7 articles about Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 175882-76-5
6-[4-Bromo-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-benzyl]-3,5,5-trimethyl-1-trimethylsilanylmethyl-cyclohex-2-enol

: 1026042-63-6
Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

Guidance literature:: With tetra(tert-butyl)-ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm950747d

Reference yield:

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 1026042-63-6
Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, RT, 3 h

2: tetrahydrofuran; pentane / -78 °C

3: t-Bu₄NF / tetrahydrofuran / 0 - 20 °C

With tetra(tert-butyl)-ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; pentane;
DOI:10.1021/jm950747d

Reference yield:

: 63272-66-2
4-bromo-2-hydroxy-5-methoxybenzaldehyde

: 1026042-63-6
Acetic acid 5-bromo-2-(2-hydroxy-4,6,6-trimethyl-2-trimethylsilanylmethyl-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole, DMAP / CH₂Cl₂ / Ambient temperature

2: NaBH₄ / methanol / 0 °C

3: Ph₃P, Br₂ / dimethylformamide / 0 °C

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, RT, 3 h

5: tetrahydrofuran; pentane / -78 °C

6: t-Bu₄NF / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; bromine; tetra(tert-butyl)-ammonium fluoride; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jm950747d