63272-66-2Relevant academic research and scientific papers
Controlled regioregularity in oligo(2-methoxy-5-(2′-ethylhexyloxy)-1, 4-phenylenevinylenes
Zhu, Xinju,Plunkett, Kyle N.
, p. 7093 - 7102 (2014/08/18)
A series of three pentameric derivatives of 2-methoxy-5-(2′- ethylhexyloxy)-p-phenylenevinylenes (2-4), with varying degrees of side chain regioregularity, was prepared. The oligomerization chemistry was carried out using repetitive Horner-Wadsworth-Emmon
Pt(IV)-catalyzed generation and [4+2]-cycloaddition reactions of o-quinone methides
Radomkit, Suttipol,Sarnpitak, Pakornwit,Tummatorn, Jumreang,Batsomboon, Paratchata,Ruchirawat, Somsak,Ploypradith, Poonsakdi
supporting information; experimental part, p. 3904 - 3914 (2011/06/22)
Novel intermolecular and intramolecular generations of ortho-quinone methides and their formal [4+2]-cycloaddition reactions with olefins catalyzed by PtCl4 and AuCl3 under mild conditions have been developed. Good to excellent yields (up to 99%) and diastereoselectivity (up to >99:1) of the chromans were obtained. PtCl4 was found to be effective and compatible with various functional groups present in the substrates. A mechanism accounting for its catalytic cycle is proposed and discussed.
FLUORESCENT PROBES FOR ZINC
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Page 10, (2008/06/13)
A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents hydrogen atom, an alkyl group, an alkoxy group, or hydroxy group; R2 represents a group represented by the following formula (A): wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or -CO-; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which comprises said compound or a salt thereof.
C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS
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Page 31-32, (2008/06/13)
The invention concerns substituted tricyclic isoxazoline derivatives according to Formula (I), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisoxazoline , dihydronaphthalenoisoxazoline and dihydrobenzothiopyranoisoxazoline derivatives substituted on the phenylpart of the tricyclic moiety with at least one radical that is attached to the phenyl radical by a carbon-carbon bond as well as processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine, in particular for treating depression, anxiety, movement disorders, psychosis, Parkinson's disease and body weight disorders including anorexia nervosa and bulimia, wherin all variables are defined in Claim 1. (I) The compounds have surprisingly been shown to have selective serotonine (5-HT) reuptake inhibitor activity in combination with additional α2-adrenoceptor antagonist activity and show a strong anti-depressant and/or anxiolytic activity and/or antipsychotic and/or a body weight control activity without being sedative. Also, in view of their selective serotonine (5-HT) reuptake inhibitor as well as α2-adrenoceptor antagonist activity, compounds according to the invention are also suitable for treatment and/or prophylaxis in diseases where either one of the activities alone or the combination of said activities may be of therapeutic use.
A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion
Maruyama, Satoko,Kikuchi, Kazuya,Hirano, Tomoya,Urano, Yasuteru,Nagano, Tetsuo
, p. 10650 - 10651 (2007/10/03)
Zn2+ plays important roles in various biological systems; as a result, the development of tools that can visualize chelatable Zn2+ has attracted much attention recently. We report here newly synthesized fluorescent sensors for Zn2+, ZnAF-Rs, whose excitation maximum is shifted by Zn2+ under physiological conditions. Thus, these sensors enable ratiometric imaging, which is a technique to reduce artifacts by minimizing the influence ofextraneous factors on the fluorescence of a probe. Ratiometric measurement can provide precise data, and some probes allow quantitative detection. ZnAF-Rs are the first ratiometric fluorescent sensors for Zn2+ that enable quantitative analysis under physiological conditions. ZnAF-Rs also possess suitable Kd for applications, and high selectivity against other biologically relevant cations, especially Ca2+. Using these probes, changes of intracellular Zn2+ concentration in cultured cells were monitored successfully. We believe that these probes will be extremely useful in studies on the biological functions of Zn2+. Copyright
Non-steroid progesterone receptor agonist and antagonist and compounds and methods
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, (2008/06/13)
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
Non-steroid androgen receptor antagonist compounds and methods
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, (2008/06/13)
Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.
