(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Base Information

Chemical Name:(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
CAS No.:1087348-18-2
Molecular Formula:C₁₈H₁₈F₃N₃O₂S
Molecular Weight:397.421
Hs Code.:

Synonyms:(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Chemical Property of (6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

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Technology Process of (6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

There total 6 articles about (6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.4%

: 1087348-59-1
(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1087348-18-2
(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one; N,N-dimethyl-formamide dimethyl acetal; at 60 ℃; for 1.5h;

With hydrazine; In ethanol; acetic acid; at 20 ℃; for 16h;

Reference yield:

: 1087348-55-7
(2S,3R)-tert-butyl 3-tert-butyldimethylsilyloxy-2-cyclopropyl-5-oxopyrrolidine-1-carboxylate

: 1087348-18-2
(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 3 h / -78 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

3.1: hydrogenchloride / 1,4-dioxane

3.2: 16 h / 0 - 20 °C

4.1: 1.5 h / 60 °C

4.2: 16 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1087348-53-5
(S)-tert-butyl 2-cyclopropyl-3,5-dioxopyrrolidine-1-carboxylate

: 1087348-18-2
(6S)-4,6-dicyclopropyl-5-(4-trifluoromethylphenylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; acetic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: tetrahydrofuran / 3 h / -78 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

5.1: hydrogenchloride / 1,4-dioxane

5.2: 16 h / 0 - 20 °C

6.1: 1.5 h / 60 °C

6.2: 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;