(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

Base Information

Chemical Name:(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one
CAS No.:1087348-59-1
Molecular Formula:C₁₇H₁₈F₃NO₃S
Molecular Weight:373.396
Hs Code.:

Synonyms:(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

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Chemical Property of (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

Chemical Property:

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Technology Process of (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

There total 5 articles about (2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1087348-58-0
(2S)-tert-butyl 2,5-dicyclopropyl-3-oxopyrrolidine-1-carboxylate

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1087348-59-1
(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

Guidance literature:: (2S)-tert-butyl 2,5-dicyclopropyl-3-oxopyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane;

4-trifluorophenylsulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 1087348-55-7
(2S,3R)-tert-butyl 3-tert-butyldimethylsilyloxy-2-cyclopropyl-5-oxopyrrolidine-1-carboxylate

: 1087348-59-1
(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / -78 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

3.1: hydrogenchloride / 1,4-dioxane

3.2: 16 h / 0 - 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1087348-53-5
(S)-tert-butyl 2-cyclopropyl-3,5-dioxopyrrolidine-1-carboxylate

: 1087348-59-1
(2S)-2,5-dicyclopropyl-1-(4-trifluoromethylphenylsulfonyl)pyrrolidin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; acetic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: tetrahydrofuran / 3 h / -78 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

5.1: hydrogenchloride / 1,4-dioxane

5.2: 16 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;