5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

Base Information

Chemical Name:5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile
CAS No.:1469772-14-2
Molecular Formula:C₂₂H₁₀Cl₂F₂N₆O
Molecular Weight:483.264
Hs Code.:

Synonyms:5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

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Chemical Property of 5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

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Technology Process of 5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

There total 4 articles about 5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1897-50-3
5-chloro-2,4,6-trifluoroisophthalonitrile

: 1469771-92-3
8-amino-5-(4-chlorophenylamino)quinazolin-4(3H)-one

: 1469772-14-2
5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

Guidance literature:: With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 75 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

: 400784-50-1
5-chloro-8-nitro-quinazolin-4(3H)-one

: 1469772-14-2
5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

3: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

: 865713-11-7
C₁₄H₉ClN₄O₃

: 1469772-14-2
5-chloro-4-(5-(4-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)-2,6-difluoroisophthalonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

2: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.068