cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate

Base Information

• Chemical Name: cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
• CAS No.: 910472-23-0
• Molecular Formula: C₁₇H₂₅NO₂S
• Molecular Weight: 307.457

Synonyms:cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate

Chemical Property of cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate

There total 2 articles about cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

cycloactanone (502-49-8) + cyclohexyl 2-cyanoacetate (52688-11-6) → cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate (910472-23-0)

Guidance literature:

With morpholine; sulfur; In N,N-dimethyl-formamide; at 70 ℃; for 18h;

DOI:10.1016/j.bmc.2006.05.035

Reference yield:

cyclohexanol (108-93-0) → cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate (910472-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂SO₄ / benzene / 2.5 h / Heating

2: 33 percent / sulfur; morpholine / dimethylformamide / 18 h / 70 °C

With morpholine; sulfuric acid; sulfur; In N,N-dimethyl-formamide; benzene; 1: Fischer esterification / 2: Gewald reaction;

DOI:10.1016/j.bmc.2006.05.035

Reference yield: 78.0%

cyclohexyl 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate (910472-23-0) + phenyl isocyanate (103-71-9) → 2-(3-phenyl-ureido)-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid cyclohexyl ester

Guidance literature:

With pyridine; at 65 ℃; for 18h;

DOI:10.1016/j.bmc.2006.05.035

upstream raw materials:

cycloactanone

cyclohexyl 2-cyanoacetate

cyclohexanol

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