(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Base Information

Chemical Name:(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol
CAS No.:1417795-78-8
Molecular Formula:C₃₇H₄₈O₃Si₂
Molecular Weight:596.957
Hs Code.:

Synonyms:(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Suppliers and Price of (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Chemical Property:

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Technology Process of (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

There total 7 articles about (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1417795-77-7
(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butyl acetate

: 1417795-78-8
(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Guidance literature:: With methanol; potassium carbonate; at 20 ℃;
DOI:10.1016/j.tet.2012.11.051

Reference yield:

: 138499-16-8
2-[(tert-butyldiphenylsilyl)oxy]ethanol

: 1417795-78-8
(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 2 h / -20 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 12 h / Reflux

3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

4.1: lipase AK from Pseudomonas fluorescens / di-isopropyl ether / 20 °C / Molecular sieve; Inert atmosphere; Enzymatic reaction

5.1: 1H-imidazole; dmap / dichloromethane / 3 h / 0 - 20 °C

6.1: potassium carbonate; methanol / 20 °C

With 1H-imidazole; methanol; dmap; lithium aluminium tetrahydride; lipase AK from Pseudomonas fluorescens; iodine; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; di-isopropyl ether; mineral oil;
DOI:10.1016/j.tet.2012.11.051

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1417795-78-8
(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole; dmap / tetrahydrofuran / 24 h / 0 - 20 °C

2.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 2 h / -20 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 12 h / Reflux

4.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

5.1: lipase AK from Pseudomonas fluorescens / di-isopropyl ether / 20 °C / Molecular sieve; Inert atmosphere; Enzymatic reaction

6.1: 1H-imidazole; dmap / dichloromethane / 3 h / 0 - 20 °C

7.1: potassium carbonate; methanol / 20 °C

With 1H-imidazole; methanol; dmap; lithium aluminium tetrahydride; lipase AK from Pseudomonas fluorescens; iodine; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; di-isopropyl ether; mineral oil;
DOI:10.1016/j.tet.2012.11.051