methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

Base Information

Chemical Name:methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate
CAS No.:1219011-11-6
Molecular Formula:C₂₀H₂₀FN₃O₄S
Molecular Weight:417.461
Hs Code.:

Synonyms:methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

Chemical Property:

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Technology Process of methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

There total 1 articles about methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219011-10-5
methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-8,9-dihydropyrido[3,2-b]indolizin-5-yl)acetate

: 1219011-11-6
methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

Guidance literature:: With hydrogen; 1% Pd/C; In ethyl acetate; for 1h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1219011-11-6
methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

: 74-88-4
methyl iodide

: 1219011-12-7
methyl {(8R)-8-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

Guidance literature:: methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate; With sodium hydride; N,N-dimethyl-formamide; In mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

methyl iodide; In mineral oil; at 20 ℃; for 1h;

Reference yield:

: 1219011-11-6
methyl ((8R)-8-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetate

: 1305196-92-2
C₂₇H₃₀FN₃O₄

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran

2: magnesium / methanol

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With sodium hydride; magnesium; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.11.084