Technology Process of N-benzyl-1-[(2-fluorophenyl)sulfonyl]-1H-pyrrole-2-carboxamide
There total 3 articles about N-benzyl-1-[(2-fluorophenyl)sulfonyl]-1H-pyrrole-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
for 18h;
Ambient temperature;
DOI:10.1016/0968-0896(96)00075-2
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) t-BuOK, 18-crown-6 / 1.) THF, 15 min, 2.) THF, RT, 3.5 h
2: 36 percent / 2 N aq. KOH / ethanol; tetrahydrofuran / Ambient temperature
3: 71 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, 4-dimethylaminopyridine / tetrahydrofuran / 18 h / Ambient temperature
With
dmap; potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; ethanol;
DOI:10.1016/0968-0896(96)00075-2
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 36 percent / 2 N aq. KOH / ethanol; tetrahydrofuran / Ambient temperature
2: 71 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, 4-dimethylaminopyridine / tetrahydrofuran / 18 h / Ambient temperature
With
dmap; potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; ethanol;
DOI:10.1016/0968-0896(96)00075-2