2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Base Information

Chemical Name:2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione
CAS No.:957785-34-1
Molecular Formula:C₄₆H₄₀N₄O₉
Molecular Weight:792.845
Hs Code.:

2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Synonyms:2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

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Chemical Property of 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

There total 19 articles about 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957785-13-6
4-chloro-5,6,8-trimethoxyquinoline-2-carboxylic acid methyl ester

: 957785-34-1
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Guidance literature:: Multi-step reaction with 13 steps

1.1: 100 percent / hydrogen; Et₃N / Pd-C / ethyl acetate / 0.75 h / 20 °C

2.1: NaH / toluene / 15 h / 110 °C

2.2: 78 percent / aq. HCl / dioxane / 15 h / 70 °C

3.1: 83 percent / NaOH / ethanol; H₂O / 15 h / 20 °C

4.1: 60 percent / potassium tert-butoxide / dimethylsulfoxide / 5 h / 100 °C

5.1: potassium carbonate; iodine monochloride / dimethylformamide / 16 h / 20 °C

6.1: 520 mg / Ag₂CO₃ / benzene / 72 h

7.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

7.2: 134 mg / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

8.1: diphenylphosphoryl azide; Et₃N / benzene / 0.25 h / Heating

8.2: LiOH / tetrahydrofuran / 1 h / 20 °C

9.1: 85 mg / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

10.1: 93 percent / cerium ammonium nitrate / acetonitrile; H₂O / 0.75 h / 0 °C

11.1: iodine azide / acetonitrile / -10 - 20 °C

12.1: NaN₃ / tetrahydrofuran; H₂O / 15 h / 20 °C

13.1: 30 mg / sodium dithionite; H₂O / methanol / 4 h / Heating

With sodium hydroxide; n-butyllithium; sodium azide; sodium dithionite; ammonium cerium(IV) nitrate; iodine(I) azide; diphenylphosphoranyl azide; potassium tert-butylate; water; hydrogen; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; silver carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jo701435p

Reference yield:

: 957785-12-5
5,6,8-trimethoxy-(1H)-quinolin-4-one-2-carboxylic acid methyl ester

: 957785-34-1
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Guidance literature:: Multi-step reaction with 14 steps

1.1: 88 percent / POCl₃ / benzene / 24 h / 20 °C

2.1: 100 percent / hydrogen; Et₃N / Pd-C / ethyl acetate / 0.75 h / 20 °C

3.1: NaH / toluene / 15 h / 110 °C

3.2: 78 percent / aq. HCl / dioxane / 15 h / 70 °C

4.1: 83 percent / NaOH / ethanol; H₂O / 15 h / 20 °C

5.1: 60 percent / potassium tert-butoxide / dimethylsulfoxide / 5 h / 100 °C

6.1: potassium carbonate; iodine monochloride / dimethylformamide / 16 h / 20 °C

7.1: 520 mg / Ag₂CO₃ / benzene / 72 h

8.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

8.2: 134 mg / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

9.1: diphenylphosphoryl azide; Et₃N / benzene / 0.25 h / Heating

9.2: LiOH / tetrahydrofuran / 1 h / 20 °C

10.1: 85 mg / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

11.1: 93 percent / cerium ammonium nitrate / acetonitrile; H₂O / 0.75 h / 0 °C

12.1: iodine azide / acetonitrile / -10 - 20 °C

13.1: NaN₃ / tetrahydrofuran; H₂O / 15 h / 20 °C

14.1: 30 mg / sodium dithionite; H₂O / methanol / 4 h / Heating

With sodium hydroxide; n-butyllithium; sodium azide; sodium dithionite; ammonium cerium(IV) nitrate; iodine(I) azide; diphenylphosphoranyl azide; potassium tert-butylate; water; hydrogen; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; silver carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jo701435p

Reference yield:

: 2-[(2,4,5-trimethoxyphenyl)amino]-2-butenedioic acid dimethyl ester

: 957785-34-1
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-7-amino-6-methoxyquinoline-5,8-dione

Guidance literature:: Multi-step reaction with 15 steps

1.1: 86 percent / diphenyl ether / 2 h / Heating

2.1: 88 percent / POCl₃ / benzene / 24 h / 20 °C

3.1: 100 percent / hydrogen; Et₃N / Pd-C / ethyl acetate / 0.75 h / 20 °C

4.1: NaH / toluene / 15 h / 110 °C

4.2: 78 percent / aq. HCl / dioxane / 15 h / 70 °C

5.1: 83 percent / NaOH / ethanol; H₂O / 15 h / 20 °C

6.1: 60 percent / potassium tert-butoxide / dimethylsulfoxide / 5 h / 100 °C

7.1: potassium carbonate; iodine monochloride / dimethylformamide / 16 h / 20 °C

8.1: 520 mg / Ag₂CO₃ / benzene / 72 h

9.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

9.2: 134 mg / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

10.1: diphenylphosphoryl azide; Et₃N / benzene / 0.25 h / Heating

10.2: LiOH / tetrahydrofuran / 1 h / 20 °C

11.1: 85 mg / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

12.1: 93 percent / cerium ammonium nitrate / acetonitrile; H₂O / 0.75 h / 0 °C

13.1: iodine azide / acetonitrile / -10 - 20 °C

14.1: NaN₃ / tetrahydrofuran; H₂O / 15 h / 20 °C

15.1: 30 mg / sodium dithionite; H₂O / methanol / 4 h / Heating

With sodium hydroxide; n-butyllithium; sodium azide; sodium dithionite; ammonium cerium(IV) nitrate; iodine(I) azide; diphenylphosphoranyl azide; potassium tert-butylate; water; hydrogen; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; silver carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; diphenylether; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jo701435p