6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile

Base Information

• Chemical Name: 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile
• CAS No.: 216167-39-4
• Molecular Formula: C₁₅H₁₄N₄O₄
• Molecular Weight: 314.301

Synonyms:6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile

Chemical Property of 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile

Chemical Property:

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Technology Process of 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile

There total 2 articles about 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-methyl-3,4-dimethoxyaniline (35162-34-6) + 6-chloro-3-nitropicolinonitrile (93683-65-9) → 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile (216167-39-4)

Guidance literature:

With pyridine; In 2-ethoxy-ethanol; at 120 - 130 ℃; for 3h;

DOI:10.1021/jm980206z

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile (216167-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NMP / 180 °C

2: 75 percent / pyridine / 2-ethoxy-ethanol / 3 h / 120 - 130 °C

With pyridine; 1-methyl-pyrrolidin-2-one; In 2-ethoxy-ethanol;

DOI:10.1021/jm980206z

Reference yield: 69.0%

6-[(3,4-Dimethoxy-phenyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile (216167-39-4) → 3-Amino-6-[(3,4-dimethoxy-phenyl)-methyl-amino]-pyridine-2-carbonitrile (216167-55-4)

Guidance literature:

With hydrogenchloride; iron; In methanol; 2-methoxy-ethanol; for 2h; Heating;

DOI:10.1021/jm980206z

upstream raw materials:

N-methyl-3,4-dimethoxyaniline

6-chloro-3-nitropicolinonitrile

2,6-dicholoro-3-nitropyridine

Downstream raw materials:

3-Amino-6-[(3,4-dimethoxy-phenyl)-methyl-amino]-pyridine-2-carbonitrile

N⁶-(3,4-Dimethoxy-phenyl)-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

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