(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

Base Information

Chemical Name:(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
CAS No.:158294-84-9
Molecular Formula:C₂₈H₃₂O₃
Molecular Weight:416.56
Hs Code.:

Synonyms:(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

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Chemical Property of (11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

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Technology Process of (11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

There total 2 articles about (11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 913081-60-4
(5α,11β,17α)-(9CI)-11-[4-(2-tetrahydro-2H-pyranyloxy)phenyl]-17,23-epoxy-5-hydroxy-19,24-dinorchola-9,20-dien-3-one cyclic 3-(1,2-ethanediyl)acetal

: 158294-84-9
(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

Guidance literature:: With oxalic acid; In acetone; for 2h; Heating;
DOI:10.1016/j.bmc.2006.05.066

Reference yield:

: 158294-84-9
(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

Guidance literature:

Reference yield:

: 158294-84-9
(11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one

: 19,24-dinorchola-4,9,20-trien-3-one,17,23-epoxy-11-(4-(dimethoxy-phosphoryl)phenyl)-, (11β,17α)-(9Cl)

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / cooling

2: N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane / palladium diacetate / 1,4-dioxane / microwave irradiation

With sodium hydride; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmc.2006.05.066