913081-60-4

Upstream product

• 155768-31-3 (5α,10α,17α)-(9CI)-5,10:17,23-diepoxy-19,24-dinorchola-9(11),20-dien-3-one cyclic 3-(1,2-ethanediyl)acetal 
• 36637-44-2 (4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide 

Downstream Products

• 913081-61-5 (11β,17α)-(9CI)-17,23-epoxy-11-(4-trifluoromethylsulfonyloxyphenyl)-19,24-dinorchola-4,9,20-trien-3-one 
• 158294-84-9 (11β,17α)-(9CI)-11-(4-hydroxyphenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one 

Relevant academic research and scientific papers

17-PHOSPHOROUS STEROID DERIVATIVES USEFUL AS PROGESTERONE RECEPTOR MODULATORS

The present invention is directed to novel 17-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor.

11-PHOSPHOROUS STEROID DERIVATIVES USEFUL AS PROGESTERONE RECEPTOR MODULATORS

The present invention is directed to novel 11-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor.

New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids

A new series of phosphorus-containing 11β-aryl-substituted steroids have been synthesized in an eight-step sequence involving a palladium-catalyzed coupling reaction to introduce a phosphorus group onto the aromatic ring. The compounds were evaluated for