(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Base Information

Chemical Name:(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:1313365-57-9
Molecular Formula:C₁₉H₂₀ClNO₃
Molecular Weight:345.826
Hs Code.:

Synonyms:(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Suppliers and Price of (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Chemical Property:

Boiling Point:526.6±50.0 °C(Predicted)
Density:1?+-.0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

There total 8 articles about (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1313365-56-8
{2-[(S)-(4-chloro-phenyl)-((S)-2-methyl-propane-2-sulfinylamino)-methyl]-4-isopropoxy-5-methoxy-phenyl}-acetic acid ethyl ester

: 1313365-57-9
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: {2-[(S)-(4-chloro-phenyl)-((S)-2-methyl-propane-2-sulfinylamino)-methyl]-4-isopropoxy-5-methoxy-phenyl}-acetic acid ethyl ester; With hydrogenchloride; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In methanol; at 20 ℃; for 0.25h; enantioselective reaction;
DOI:10.1021/acs.jmedchem.5b00810

Reference yield: 45.0%

: 1313366-29-8
1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1313365-57-9
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (1R)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2,4-dihydro-1H-isoquinolin-3-one

Guidance literature:: Resolution of racemate;

Reference yield:

: 14064-15-4
(4-chlorophenyl)trimethylstannane

: 1313365-57-9
(S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate / tetrahydrofuran / 20 - 60 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 0.5 h / 20 °C

2.2: 0.25 h / 20 °C

With hydrogenchloride; bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In tetrahydrofuran; methanol;