(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Base Information

Chemical Name:(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:1416952-67-4
Molecular Formula:C₃₂H₃₆ClNO₅S
Molecular Weight:582.161
Hs Code.:

Synonyms:(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Chemical Property of (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

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Technology Process of (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

There total 14 articles about (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4526-07-2
1,4-bis(trimethylsilyl)-1,3-butadiyne

: 589-87-7
1,4-bromoiodobenzene

: 66228-76-0
4-(trimethylsilylethynyl)phenylacetylene

: 1416952-67-4
(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-(8,8-dioxo-8-thia-bicyclo[3.2.1]oct-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1408003-66-6
1-bromo-4-[4-(trimethylsilyl)-1,3-butadiyn-1-yl]benzene

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; diastereoselective reaction; Sealed tube;
DOI:10.1039/c3cc42079e

Reference yield:

: 4526-07-2
1,4-bis(trimethylsilyl)-1,3-butadiyne

: 589-87-7
1,4-bromoiodobenzene

: 66228-76-0
4-(trimethylsilylethynyl)phenylacetylene

: 1416952-67-4
(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-(8,8-dioxo-8-thia-bicyclo[3.2.1]oct-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1408003-66-6
1-bromo-4-[4-(trimethylsilyl)-1,3-butadiyn-1-yl]benzene

: (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-(8,8-dioxo-8-thia-bicyclo[3.2.1]oct-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1416952-68-5
(S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; diastereoselective reaction; Sealed tube;
DOI:10.1039/c3cc42079e

Reference yield:

: 4526-07-2
1,4-bis(trimethylsilyl)-1,3-butadiyne

: 589-87-7
1,4-bromoiodobenzene

: 66228-76-0
4-(trimethylsilylethynyl)phenylacetylene

: 1416952-67-4
(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-hydroxy-1-(1-oxo-hexahydro-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-(8,8-dioxo-8-thia-bicyclo[3.2.1]oct-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1408003-66-6
1-bromo-4-[4-(trimethylsilyl)-1,3-butadiyn-1-yl]benzene

: (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-(8,8-dioxo-8-thia-bicyclo[3.2.1]oct-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1416952-68-5
(S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-(9,9-dioxo-9-thia-bicyclo[3.3.1]non-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: 1416910-09-2
(S)-1-(4-chloro-phenyl)-2-{4-[(R)-1-(1,1-dioxo-hexahydro-1-thiopyran-4-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-(9,9-dioxo-9-thia-bicyclo[3.3.1]non-3-yl)-1-hydroxy-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; diastereoselective reaction; Sealed tube;
DOI:10.1039/c3cc42079e