ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

Base Information

Chemical Name:ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate
CAS No.:869297-89-2
Molecular Formula:C₁₈H₁₅N₃O₄S
Molecular Weight:369.401
Hs Code.:

Synonyms:ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

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Chemical Property of ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

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Technology Process of ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

There total 5 articles about ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 869296-11-7
ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

: 874-89-5
4-Cyanobenzyl alcohol

: 869297-89-2
ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

Guidance literature:: 4-Cyanobenzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 10 - 35 ℃; for 0.166667h;

ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate; In tetrahydrofuran; mineral oil; for 1h; Further stages;

Reference yield: 52.0%

: 869296-11-7
ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

: 64-17-5
ethanol

: 874-89-5
4-Cyanobenzyl alcohol

: 869297-89-2
ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

Guidance literature:: 4-Cyanobenzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

ethanol; Further stages;
DOI:10.1016/j.bmc.2014.07.025

Reference yield:

: 869296-11-7
ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

: 874-89-5
4-Cyanobenzyl alcohol

: 869297-89-2
ethyl 5-({[(4-cyanophenyl)methyl]oxy}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

: C₁₆H₁₁N₃O₄S

Guidance literature:: 4-Cyanobenzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

ethyl 5-(bromomethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.07.025