(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide
CAS No.:205534-29-8
Molecular Formula:C₁₄H₁₈N₂O₂
Molecular Weight:246.309
Hs Code.:

Synonyms:(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

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Chemical Property of (2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

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Technology Process of (2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

There total 4 articles about (2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 205534-28-7
(2R,3R)-3-Methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

: 205534-29-8
(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo971388s

Reference yield:

: 141632-86-2
(1'S,6R)-1-benzyloxycarbonyl-3-(1'-phenyleth-1'-yl)-6-methylperihydropyrimidin-4-one

: 205534-29-8
(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiHMDS, 2.) TsCl / 1.) THF, 0 deg C, 30 min, 2.) THF, -30 deg C, 1 h

2: 70 percent / 11M HCl / ethanol / 2 h / Heating

3: 95 percent / NH₃ gas / dimethylsulfoxide / 16 h

4: 85 percent / DMAP, pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; hydrogenchloride; dmap; ammonia; p-toluenesulfonyl chloride; lithium hexamethyldisilazane; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo971388s

Reference yield:

: 205534-27-6
(1'S,2S,3R)-N-(1'-phenylethyl)-3-amino-2-chlorobutanamide

: 205534-29-8
(2R,3R)-1-Acetyl-3-methyl-aziridine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NH₃ gas / dimethylsulfoxide / 16 h

2: 85 percent / DMAP, pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; dmap; ammonia; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo971388s