2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

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Chemical Name:2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid
CAS No.:1268485-26-2
Molecular Formula:C₄₄H₄₄N₄O₂S₃
Molecular Weight:757.057
Hs Code.:

Synonyms:2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

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Chemical Property of 2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

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Technology Process of 2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

There total 4 articles about 2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

: 1268485-34-2
5-(5'-(4-(diphenylamino)phenyl)-4,4'-dihexyl-2,2'-bithiazol-5-yl)thiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1268485-26-2
2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

Guidance literature:: With ammonium acetate; acetic acid; at 120 ℃; for 12h;
DOI:10.1039/c0jm03811c

Reference yield:

: 1268485-33-1
5-(5'-bromo-4,4'-dihexyl-2,2'-bithiazol-5-yl)thiophene-2-carbaldehyde

: 201802-67-7
4-(diphenylamino)phenyl boronic acid

: 1268485-26-2
2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 0.5 h / 45 °C / Inert atmosphere

1.2: 12 h / Reflux

2.1: ammonium acetate; acetic acid / 6 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; acetic acid; In tetrahydrofuran; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling / 2.1: |Knoevenagel Condensation;
DOI:10.1039/c3ra00181d

Reference yield:

: 180729-93-5
5,5′-dibromo-4,4′-dibutyl-2,2′-bisthiazole

: 1268485-26-2
2-cyano-3-(5-{5'-[4-(diphenylamino)phenyl]-4,4'-dihexyl-2,2'-bithiazol-5-yl-4,4'-dihexyl-2,2'-bithiazol-5-yl}thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

3: ammonium acetate; acetic acid / 12 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; acetic acid; In tetrahydrofuran; water; 1: Suzuki coupling / 2: Suzuki coupling / 3: Knoevenagel condensation;
DOI:10.1039/c0jm03811c