Technology Process of 4-(aminomethyl)-N-(4-(2-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide hydrochloride
There total 8 articles about 4-(aminomethyl)-N-(4-(2-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether; dichloromethane;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 12 h / Reflux
2.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere
3.2: 0.33 h / 0 - 20 °C
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C
4.2: 0 °C
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C
5.2: 16 h / 0 - 20 °C
6.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 0 - 20 °C
With
pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; acetic acid / 10% palladium on charcoal / ethanol / 24 h / 5171.62 Torr
2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere
2.2: 0.33 h / 0 - 20 °C
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 20 °C
3.2: 0 °C
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C
4.2: 16 h / 0 - 20 °C
5.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 0 - 20 °C
With
pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU;
10% palladium on charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
