30041-95-3

Basic information

• Product Name: (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (4-cyanophenoxy)-aceticaciethylester;(4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER
• CAS NO: 30041-95-3
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 30041-95-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 337°Cat760mmHg
• Flash Point: 146.9°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(30041-95-3)
• EPA Substance Registry System: (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(30041-95-3)

Safety Data

• Hazardous Substances Data: 30041-95-3(Hazardous Substances Data)

Usage

General Description

The chemical (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER, also known as ethyl (4-cyanophenoxy)acetate, is an ester compound that is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is derived from the combination of ethyl acetate and 4-cyanophenol, and is often used as a building block for the production of other chemicals. (4-CYANOPHENOXY) ACETIC ACID ETHYL ESTER has a wide range of applications in the chemical industry, and its properties make it suitable for use in various chemical reactions and processes. Additionally, it has potential uses in the development of new drugs and advanced materials due to its unique chemical structure and reactivity.

InChI:InChI=1/C11H11NO3/c1-2-14-11(13)8-15-10-5-3-9(7-12)4-6-10/h3-6H,2,8H2,1H3

Upstream product

• 767-00-0 4-cyanophenol 
• 105-36-2 ethyl bromoacetate 
• 1073-72-9 4-hydroxythioanisole 
• 557-21-1 zinc(II) cyanide 
• 15267-46-6 ethyl 2-(4-methylsulfanylphenoxy)acetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 57929-14-3 ethyl (4-ethoxy-carbonimidoyl-phenoxy)-acetate hydrochloride 
• 1272519-95-5 (Z)-methyl-2-(4-(5-(4-methoxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)phenoxy)acetate 
• 1610785-03-9 N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(4-cyanophenoxy)acetamide 
• 695211-56-4 ethyl 2-(4-(1H-tetrazol-5-yl)phenoxy)acetate 
• 1541987-92-1 4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile 
• 55368-68-8 2-(4-cyanophenoxy)acetyl chloride 
• 1541987-89-6 N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide 
• 1878-82-6 (4-cyanophenoxy)acetic acid 
• 1541988-24-2 4-[2-[(4-cyanophenoxy)methyl]-3-methyl-3H-imidazo[4,5-b]-pyridin-5-yl]benzonitrile 
• 1541988-22-0 4-[(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzonitrile 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Aryl Thioethers

A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C-S bond activation and a C-C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction's utility across organic chemistry.

HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME

The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Design and synthesis of heterocyclic cations for specific DNA recognition: From AT-rich to mixed-base-pair DNA sequences

The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove. Modifications were introduced in the original compound to include an H-bond accepting group to specifically recognize the G-NH that projects into the minor groove. Therefore, a series of heterocyclic cations substituted with an azabenzimidazole ring has been designed and synthesized for mixed-base-pair DNA recognition. The most successful compound, 12a, had an azabenzimidazole to recognize G and additional modifications for general minor groove interactions. It binds to the DNA site -AAAGTTT- more strongly than the -AAATTT- site without GC and indicates the design success. Structural modifications of 12a generally weakened binding. The interactions of the new compound with a variety of DNA sequences with and without GC base pairs were evaluated by thermal melting analysis, circular dichroism, fluorescence emission spectroscopy, surface plasmon resonance, and molecular modeling.