N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

Base Information

Chemical Name:N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride
CAS No.:1039733-13-5
Molecular Formula:C₂₇H₂₆FN₅O*ClH
Molecular Weight:491.996
Hs Code.:

Synonyms:N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

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Chemical Property of N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

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Technology Process of N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

There total 7 articles about N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1039733-00-0
N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 6336-44-3,7547-97-9,88982-39-2,7547-96-8
cis-1-propenylboronic acid

: 1039733-13-5
N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

Guidance literature:: N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide; cis-1-propenylboronic acid; With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In Dimethyl ether; at 100 ℃; for 0.25h; Microwave irradiation;

With hydrogenchloride;

Reference yield:

: 959237-34-4
2,4-dichloro-7-iodoquinazoline

: 1039733-13-5
N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: tetrahydrofuran; water / 26 h / 100 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / Dimethyl ether / 0.25 h / 100 °C / Microwave irradiation

With sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Dimethyl ether; dichloromethane; water;

Reference yield:

: 959236-72-7
7-iodoquinazoline-2,4(1H,3H)-dione

: 1039733-13-5
N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-aniline / 6 h / 115 °C

1.2: pH 5 - 7

2.1: triethylamine / dichloromethane / 20 h / 20 °C

3.1: tetrahydrofuran; water / 26 h / 100 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / Dimethyl ether / 0.25 h / 100 °C / Microwave irradiation

With sodium hydrogencarbonate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Dimethyl ether; dichloromethane; water; N,N-dimethyl-aniline;