4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

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Chemical Name:4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester
CAS No.:350671-48-6
Molecular Formula:C₄₇H₅₃N₃O₁₂
Molecular Weight:851.951
Hs Code.:

4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

Synonyms:4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

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Chemical Property of 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

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Technology Process of 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

There total 2 articles about 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 233744-17-7
[(2R,3R,4S,5R,6S)-5-(4-Amino-benzyloxy)-3,4-bis-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: pentanedioic acid mono-[4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl] ester

: 350671-48-6
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

Guidance literature:: With dacarbazine; In dichloromethane;
DOI:10.1055/s-2001-13392

Reference yield:

: 233744-16-6
[(2R,3R,4S,5R,6S)-3,4-Bis-benzyloxy-6-methoxy-5-(4-nitro-benzyloxy)-tetrahydro-pyran-2-yl]-methanol

: 350671-48-6
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH₄; NiCl₂*6H₂O / methanol

2: 94 percent / DIC / CH₂Cl₂

With sodium tetrahydroborate; dacarbazine; nickel dichloride; In methanol; dichloromethane;
DOI:10.1055/s-2001-13392

Reference yield:

: phenyl 2,3,4-tri-O-benzyl-6-O-trichloroethoxycarbonyl-D-thioglucopyranoside

: 350671-48-6
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid 4-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-ylmethyl)-benzyl ester

: C₇₇H₈₂Cl₃N₃O₁₉

: C₇₇H₈₂Cl₃N₃O₁₉

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; iodosylbenzene; 4 A molecular sieve; In 1,4-dioxane; diethyl ether; at -10 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1055/s-2001-13392