3-chloro-2-fluoro-6-iodoaniline

Base Information

Chemical Name:3-chloro-2-fluoro-6-iodoaniline
CAS No.:1268684-06-5
Molecular Formula:C₆H₄ClFIN
Molecular Weight:271.46
Hs Code.:

Synonyms:3-chloro-2-fluoro-6-iodoaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-2-fluoro-6-iodoaniline

Chemical Property:

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Technology Process of 3-chloro-2-fluoro-6-iodoaniline

There total 1 articles about 3-chloro-2-fluoro-6-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2106-04-9
3-chloro-2-fluoroaniline

: 1268684-06-5
3-chloro-2-fluoro-6-iodoaniline

: 874840-61-6
3-chloro-2-fluoro-4-iodoaniline

Guidance literature:: With N-iodo-succinimide; In dichloromethane; at 20 ℃; for 96h;

Reference yield:

: 1268684-06-5
3-chloro-2-fluoro-6-iodoaniline

: 766-05-2
cyclohexane carbonitrile

: 1268684-05-4
C₁₃H₁₅ClFIN₂

Guidance literature:: With trimethylaluminum; In toluene; at 110 ℃;
DOI:10.1016/j.bmcl.2014.03.039

Reference yield:

: 1268684-06-5
3-chloro-2-fluoro-6-iodoaniline

: C₂₆H₂₄Cl₂F₂N₆O₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: trimethylaluminum / toluene / 110 °C

2.1: sodium hydrogencarbonate / 2 h / 20 °C

2.2: 1 h / 120 °C

3.1: palladium diacetate; triphenylphosphine; triethylamine / 20 h / 20 °C

4.1: cyclohexene; dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 °C

4.2: 20 °C

5.1: N-Bromosuccinimide / acetonitrile / 8 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; water / 18 h / 100 °C

7.1: boron trifluoride diethyl etherate / dichloromethane; cyclohexene / 3 h / 20 °C

8.1: lithium hydroxide / 1,4-dioxane; water / 3 h / 70 °C

9.1: hydrazine; 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 20 °C

10.1: sodium hydrogencarbonate / 1,4-dioxane; water / 6 h / 20 °C

11.1: hydrogenchloride / 1,4-dioxane / 72 h / 20 °C

12.1: triethylamine; dmap / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-( 1H-7-azabenzotniazol-1-yl)-1,1,3,3-tetrarmethyluroniumhexafluorophosphate methanaminium; dimethylsulfide borane complex; boron trifluoride diethyl etherate; trimethylaluminum; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; lithium hydroxide; hydrazine; cyclohexene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; cyclohexene; 3.1: |Sonogashira Cross-Coupling / 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.039