4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

Base Information

Chemical Name:4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride
CAS No.:1207339-90-9
Molecular Formula:C₂₈H₃₃N₃O*ClH
Molecular Weight:464.05
Hs Code.:

Synonyms:4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

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Chemical Property of 4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

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Technology Process of 4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

There total 4 articles about 4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1207339-87-4
2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

: 1207339-90-9
4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

Guidance literature:: With hydrogenchloride; acetyl chloride; In methanol; at 0 ℃;
DOI:10.1021/jm300573d

Reference yield:

: 503272-01-3
4-(2-nitrophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 1207339-90-9
4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron / acetic acid / 0.75 h / 85 °C

2.1: sodium; 18-crown-6 ether / 1,4-dioxane / 20.5 h / Reflux

3.1: triethylamine; trichlorophosphate / 6 h / 120 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

4.2: 1 h / 146 °C

5.1: acetyl chloride; hydrogenchloride / methanol / 0 °C

With hydrogenchloride; 18-crown-6 ether; sodium; iron; sodium hydride; triethylamine; acetyl chloride; trichlorophosphate; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/jm300573d

Reference yield:

: 748159-52-6
2H-pyrrolo[3,4-c]quinolin-4(5H)-one

: 1207339-90-9
4-{[1-(2-phenyl)ethylpiperid-4-yl]methoxy}-2-isopropyl-2H-pyrrolo[3,4-c]quinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium; 18-crown-6 ether / 1,4-dioxane / 20.5 h / Reflux

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

4.1: acetyl chloride; hydrogenchloride / methanol / 0 °C

With hydrogenchloride; 18-crown-6 ether; sodium; sodium hydride; triethylamine; acetyl chloride; trichlorophosphate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/jm300573d