2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

Base Information

Chemical Name:2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline
CAS No.:1207339-87-4
Molecular Formula:C₂₈H₃₃N₃O
Molecular Weight:427.59
Hs Code.:

Synonyms:2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

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Chemical Property of 2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

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Technology Process of 2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

There total 3 articles about 2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 67686-02-6
1-(2-phenylethyl)-4-(hydroxymethyl)piperidine

: 1207340-34-8
4-chloro-2-isopropyl-2H-pyrrolo[3,4-c]quinoline

: 1207339-87-4
2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

Guidance literature:: 1-(2-phenylethyl)-4-(hydroxymethyl)piperidine; With sodium hydride; In paraffin oil (nujol); N,N-dimethyl-formamide; at 20 ℃;

4-chloro-2-isopropyl-2H-pyrrolo[3,4-c]quinoline; In paraffin oil (nujol); N,N-dimethyl-formamide; at 146 ℃;

Reference yield:

: 748159-52-6
2H-pyrrolo[3,4-c]quinolin-4(5H)-one

: 1207339-87-4
2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium; 18-crown-6 ether / 1,4-dioxane / 20.5 h / Reflux

2.1: triethylamine; trichlorophosphate / 6 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

3.2: 1 h / 146 °C

With 18-crown-6 ether; sodium; sodium hydride; triethylamine; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/jm300573d

Reference yield:

: 66757-87-7
2-nitro-benzenepropanoic acid ethyl ester

: 1207339-87-4
2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / diethyl ether; dimethyl sulfoxide; paraffin oil / 0.42 h / 20 °C / Inert atmosphere

2.1: iron / acetic acid / 0.75 h / 85 °C

3.1: sodium; 18-crown-6 ether / 1,4-dioxane / 20.5 h / Reflux

4.1: triethylamine; trichlorophosphate / 6 h / 120 °C

5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 10 min / 20 °C

5.2: 1 h / 146 °C

With 18-crown-6 ether; sodium; iron; sodium hydride; triethylamine; trichlorophosphate; In 1,4-dioxane; diethyl ether; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/jm300573d