(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

Base Information

Chemical Name:(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide
CAS No.:140661-04-7
Molecular Formula:C₂₇H₄₈N₆O₅
Molecular Weight:536.715
Hs Code.:

Synonyms:(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

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Technology Process of (2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

There total 5 articles about (2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140661-03-6
(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxyl-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>(tert-butyloxycarbonyl)L-histidinamide

: 140661-04-7
(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4h; Yield given;
DOI:10.1021/jm00088a007

Reference yield:

: 622-40-2
2-(morpholin-4-yl)ethanol

: 140661-04-7
(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine, diphenylphosphoryl azide / 1.) toluene, 65 deg C, 2 h, 2.) toluene, 85 deg C, 24 h

2: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

3: 2.) HOAc / 1 a.) CH₂Cl₂, 0 deg C, 6 h, b.) RT, 14 h, 2.) THF, water, 50 deg C, 5 h

4: TFA / CH₂Cl₂ / 4 h / 0 °C

With diphenylphosphoranyl azide; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00088a007

Reference yield:

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 140661-04-7
(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxy-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>-L-histidinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine, diphenylphosphoryl azide / 1.) toluene, 65 deg C, 2 h, 2.) toluene, 85 deg C, 24 h

2: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

3: 2.) HOAc / 1 a.) CH₂Cl₂, 0 deg C, 6 h, b.) RT, 14 h, 2.) THF, water, 50 deg C, 5 h

4: TFA / CH₂Cl₂ / 4 h / 0 °C

With diphenylphosphoranyl azide; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00088a007