N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

Base Information

Chemical Name:N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester
CAS No.:220507-49-3
Molecular Formula:C₂₉H₃₂N₂O₃S
Molecular Weight:488.651
Hs Code.:

Synonyms:N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

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Chemical Property of N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

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Technology Process of N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

There total 5 articles about N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3696-28-4
2,2'-dipyridyl disulfide bis-N-oxide

: 1027177-91-8
N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid

: 220507-49-3
N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

Guidance literature:: With tributylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo981538e

Reference yield:

: 64244-87-7
2-chlorocarbonyl-2-methylpropanoic acid ethyl ester

: 220507-49-3
N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 95 percent / LiOH / ethanol; H₂O / 5 h / Heating

3: 68 percent / tributylphosphine / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; lithium hydroxide; tributylphosphine; triethylamine; In ethanol; dichloromethane; water; 1: Acylation / 2: Hydrolysis / 3: Esterification;
DOI:10.1021/jo981538e

Reference yield:

: 4801-15-4
3-bromo-1,1-diphenyl-1-propene

: 220507-49-3
N-butyl-N-(3,3-diphenyl-2-propenyl)dimethylmalonamic acid 2-thioxo-2H-pyridine-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / tetrahydrofuran / 20 °C

2: 71 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

3: 95 percent / LiOH / ethanol; H₂O / 5 h / Heating

4: 68 percent / tributylphosphine / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; lithium hydroxide; tributylphosphine; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 1: Alkylation / 2: Acylation / 3: Hydrolysis / 4: Esterification;
DOI:10.1021/jo981538e