(R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Base Information

• Chemical Name: (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide
• CAS No.: 1206635-12-2
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 1206635-12-2.mol

Synonyms:(R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Chemical Property of (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

There total 1 articles about (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

N-(benzyloxycarbonyl)-D-serine (6081-61-4) + 4-isopropylbenzylamine hydrochloride (59528-28-8) → (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide (1206635-12-2)

Guidance literature:

N-(benzyloxycarbonyl)-D-serine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

4-isopropylbenzylamine hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm901563p

Reference yield: 100.0%

(R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide (1206635-12-2) + methyl iodide (74-88-4) → (R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-methoxypropionamide (1206635-13-3)

Guidance literature:

With silver(l) oxide; In acetonitrile; at 20 ℃; for 72h; Inert atmosphere; Darkness;

DOI:10.1021/jm901563p

upstream raw materials:

N-(benzyloxycarbonyl)-D-serine

4-isopropylbenzylamine hydrochloride

Downstream raw materials:

(R)-N-4-(isopropyl)benzyl 2-(benzyloxycarbonyl)amino-3-methoxypropionamide