6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

Base Information

Chemical Name:6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one
CAS No.:76449-32-6
Molecular Formula:C₂₇H₃₂O₅
Molecular Weight:436.548
Hs Code.:

Synonyms:6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

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Chemical Property of 6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

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Technology Process of 6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

There total 5 articles about 6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 76449-30-4
2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

: 76449-32-6
6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1248/cpb.28.2468

Reference yield:

: 70833-74-8
2-formylmethyl-2-methylcyclopentane-1,3-dione diethylene ketal

: 76449-32-6
6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / sodium amide / tetrahydrofuran; liquid ammonia / 2 h / -78 °C

2: 60 percent / sodium / tetrahydrofuran; liquid ammonia / 0.83 h / -78 °C

3: 78.3 percent / NaH (50 percent oil dispersion) / tetrahydrofuran / 15 h / Heating

4: 85.7 percent / 10 percent aq. hydrochloric acid / tetrahydrofuran / 4 h / Ambient temperature

With hydrogenchloride; sodium; sodium hydride; sodium amide; In tetrahydrofuran; ammonia;
DOI:10.1248/cpb.28.2468

Reference yield:

: 58111-66-3
1-cyano-5-methoxy-3-methyl-benzocyclobutene

: 76449-32-6
6-[2-Benzyloxy-2-(4-methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / sodium amide / tetrahydrofuran; liquid ammonia / 2 h / -78 °C

2: 60 percent / sodium / tetrahydrofuran; liquid ammonia / 0.83 h / -78 °C

3: 78.3 percent / NaH (50 percent oil dispersion) / tetrahydrofuran / 15 h / Heating

4: 85.7 percent / 10 percent aq. hydrochloric acid / tetrahydrofuran / 4 h / Ambient temperature

With hydrogenchloride; sodium; sodium hydride; sodium amide; In tetrahydrofuran; ammonia;
DOI:10.1248/cpb.28.2468