2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

Base Information

Chemical Name:2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal
CAS No.:76449-30-4
Molecular Formula:C₂₉H₃₆O₆
Molecular Weight:480.601
Hs Code.:

Synonyms:2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

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Chemical Property of 2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

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Technology Process of 2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

There total 4 articles about 2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

: 100-39-0
benzyl bromide

: 76449-28-0
1-(4-Methoxy-2-methyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-2-(6-methyl-1,4,8,11-tetraoxa-dispiro[4.1.4.2]tridec-6-yl)-ethanol

: 76449-30-4
2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 15h; Heating;
DOI:10.1248/cpb.28.2468

Reference yield:

: 70833-74-8
2-formylmethyl-2-methylcyclopentane-1,3-dione diethylene ketal

: 76449-30-4
2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / sodium amide / tetrahydrofuran; liquid ammonia / 2 h / -78 °C

2: 60 percent / sodium / tetrahydrofuran; liquid ammonia / 0.83 h / -78 °C

3: 78.3 percent / NaH (50 percent oil dispersion) / tetrahydrofuran / 15 h / Heating

With sodium; sodium hydride; sodium amide; In tetrahydrofuran; ammonia;
DOI:10.1248/cpb.28.2468

Reference yield:

: 58111-66-3
1-cyano-5-methoxy-3-methyl-benzocyclobutene

: 76449-30-4
2-(2-benzyloxy-2-(5-methoxy-3-methyl)benzocyclobuten-1-yl)ethyl-2-methylcyclopentane-1,3-dione diethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / sodium amide / tetrahydrofuran; liquid ammonia / 2 h / -78 °C

2: 60 percent / sodium / tetrahydrofuran; liquid ammonia / 0.83 h / -78 °C

3: 78.3 percent / NaH (50 percent oil dispersion) / tetrahydrofuran / 15 h / Heating

With sodium; sodium hydride; sodium amide; In tetrahydrofuran; ammonia;
DOI:10.1248/cpb.28.2468