ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate

Base Information

• Chemical Name: ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate
• CAS No.: 1620387-79-2
• Molecular Formula: C₁₇H₁₄F₂N₂O₃
• Molecular Weight: 332.307
• Mol file: 1620387-79-2.mol

Synonyms:ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate

Chemical Property of ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate

There total 1 articles about ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + 4,4'-Difluorobenzophenone (345-92-6) → ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate (1620387-79-2)

Guidance literature:

diazoacetic acid ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.416667h;

4,4'-Difluorobenzophenone; In tetrahydrofuran; at -78 ℃; for 0.416667h;

With acetic acid; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

DOI:10.1039/c9cc08559a

Reference yield: 93.0%

ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate (1620387-79-2) → ethyl 2-bromo-2,3-bis(4-fluorophenyl)-3-oxopropanoate (1620387-96-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c4cc04154b

Reference yield: 84.0%

ethyl 2-diazo-3,3-bis(4-fluorophenyl)-3-hydroxypropanoate (1620387-79-2) + tert-butyl allyl carbonate (70122-89-3) → ethyl 2-(4-fluorobenzoyl)-2-(4-fluorophenyl)pent-4-enoate

Guidance literature:

With rhodium(II) pivalate; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9cc08559a

upstream raw materials:

diazoacetic acid ethyl ester

4,4'-Difluorobenzophenone

Downstream raw materials:

ethyl 2-bromo-2,3-bis(4-fluorophenyl)-3-oxopropanoate

ethyl 2-chloro-2,3-bis(4-fluorophenyl)-3-oxopropanoate