7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

Base Information

Chemical Name:7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde
CAS No.:1031685-75-2
Molecular Formula:C₁₅H₁₄O₅S
Molecular Weight:306.339
Hs Code.:

Synonyms:7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

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Technology Process of 7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

There total 3 articles about 7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 852054-42-3
7-bromo-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carbaldehyde

: 1031685-75-2
7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h; Inert atmosphere;
DOI:10.1002/cmdc.201900225

Reference yield: 69.0%

: 593231-56-2
7-iodo-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carbaldehyde

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1031685-75-2
7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 130 ℃; for 2h;
DOI:10.1016/j.tetlet.2008.03.074

Reference yield:

: 204905-77-1
3,4-ethylenedioxythiophene-2-carboxaldehyde

: 1031685-75-2
7-(3,4-dimethoxyphenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 14 h / 20 °C / Darkness

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; water / N,N-dimethyl-formamide / 48 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; In N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1002/cmdc.201900225