3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

Base Information

Chemical Name:3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate
CAS No.:1373610-35-5
Molecular Formula:C₁₇H₁₇NO₇
Molecular Weight:347.324
Hs Code.:

Synonyms:3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

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Chemical Property of 3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

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Technology Process of 3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

There total 1 articles about 3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 924-44-7
glyoxylic acid ethyl ester

: 93098-69-2
2–(4–cyanobenzylidene)dimethyl malonate

: 1373610-35-5
3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

Guidance literature:: With 2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; triethylamine; In toluene; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja3027136

Reference yield: 88.0%

: 1373610-35-5
3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

: 1373610-51-5
(2R,3R,4R)-2-ethyl 4-methyl 3-(4-cyanophenyl)-5-oxotetrahydrofuran-2,4-dicarboxylate

Guidance literature:: With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; C₄₀H₃₂N₂O₂S; triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 16.5h; optical yield given as %ee; stereoselective reaction; Inert atmosphere; Resolution of racemate;
DOI:10.1021/ja3027136

Reference yield:

: 1373610-35-5
3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate

: 2-ethyl 4-methyl 3-(4-cyanophenyl)-5-oxotetrahydrofuran-2,4-dicarboxylate

Guidance literature:: 3-ethyl 1,1-dimethyl 2-(4-cyanophenyl)-3-oxopropane-1,1,3-tricarboxylate; With sodium tetrahydroborate; In methanol; at 20 ℃;

With formic acid; triethylamine; In tetrahydrofuran; at 70 ℃; for 1h;
DOI:10.1021/ja3027136