ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Base Information

Chemical Name:ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate
CAS No.:1160685-35-7
Molecular Formula:C₂₅H₁₈BrF₂N₃O₄
Molecular Weight:542.336
Hs Code.:

Synonyms:ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

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Chemical Property of ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Chemical Property:

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Technology Process of ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

There total 5 articles about ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849062-37-9
(3-bromo-5-fluorophenyl)boronic acid

: 1160682-59-6
ethyl N-[(7-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate

: 1160685-34-6
ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

: 1160685-35-7
ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-34-6
ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

: 1160685-35-7
ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethanol; acetonitrile / 3 h / Reflux

5.2: 1 h / 60 °C

6.1: boron tribromide / dichloromethane / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

With ammonium hydroxide; tin(II) chloride dihdyrate; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; nitric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160685-34-6
ethyl N-{[7-(3-bromo-5-fluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

: 1160685-35-7
ethyl N-{[7-(3'-bromo-5,5'-difluoro-3-biphenylyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: tin(II) chloride dihdyrate / ethanol; acetonitrile / 3 h / Reflux

3.2: 1 h / 60 °C

4.1: boron tribromide / dichloromethane / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

With tin(II) chloride dihdyrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; boron tribromide; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; mineral oil;