3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1341213-35-1
Molecular Formula:C₁₈H₁₁F₂N₃O₂S
Molecular Weight:371.367
Hs Code.:

Synonyms:3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 1 articles about 3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 886547-94-0
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 685517-71-9
2,6-difluoro-4-iodopyridine

: 1341213-35-1
3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 3.5h;
DOI:10.1021/ml300348c

Reference yield:

: 1341213-35-1
3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1421430-96-7
trans-4-(6-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-ylamino)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.58 h / 150 - 160 °C / Microwave irradiation

2: sodium hydroxide / 1,4-dioxane / 2 h / 50 °C

With sodium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1021/ml300348c

Reference yield:

: 1341213-35-1
3-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: C₁₈H₂₀FN₅*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 2 h / 50 °C

2: ethanol / 1 h / 170 °C / Microwave irradiation

With sodium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1021/ml300348c