5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Base Information

Chemical Name:5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide
CAS No.:1092565-38-2
Molecular Formula:C₂₇H₁₆F₂N₄O₃S
Molecular Weight:514.512
Hs Code.:

Synonyms:5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

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Chemical Property of 5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

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Technology Process of 5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

There total 3 articles about 5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1092565-39-3
8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yltrifluoromethanesulfonate

: 1083326-30-0
N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

: 1092565-38-2
5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: With water; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 66h;

Reference yield:

: 1083326-16-2
5-bromo-N-(2,4-difluorophenyl)pyridine-3-sulphonamide

: 1092565-38-2
5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C / Sealed tube

2: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 66 h / 100 °C

With water; potassium acetate; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane;

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1092565-38-2
5-[8-(1-benzofuran-2-yl)-1,5-naphthyridin-2-yl]-N-(2,4-difluorophenyl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0.57 h / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C / Sealed tube

3: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 66 h / 100 °C

With pyridine; water; potassium acetate; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane;