N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

Base Information

Chemical Name:N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide
CAS No.:1083326-30-0
Molecular Formula:C₁₇H₁₉BF₂N₂O₄S
Molecular Weight:396.223
Hs Code.:

Synonyms:N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

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Chemical Property of N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

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Technology Process of N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

There total 3 articles about N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1083326-16-2
5-bromo-N-(2,4-difluorophenyl)pyridine-3-sulphonamide

: 73183-34-3
bis(pinacol)diborane

: 1083326-30-0
N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 5h; Sealed tube;

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1083326-30-0
N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 - 45 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / Reflux; Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dichloromethane; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.05.048

Reference yield:

: 65001-21-0
5-bromopyridine-3-sulphonyl chloride

: 1083326-30-0
N-(2,4-difluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 - 45 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / Reflux; Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dichloromethane; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.05.048