Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

Base Information

Chemical Name:Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide
CAS No.:117523-68-9
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

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Chemical Property of Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

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Technology Process of Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

There total 4 articles about Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 26214-65-3
furan-3-carbonyl chloride

: 117523-88-3
1-phenethyl-4-piperidine

: 117523-68-9
Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

Guidance literature:: With triethylamine; In chloroform; for 0.5h; Ambient temperature;
DOI:10.1021/jm00123a028

Reference yield:

: 488-93-7
3-Furoic acid

: 117523-68-9
Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 44 h / Ambient temperature

2: 55 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform;
DOI:10.1021/jm00123a028

Reference yield:

: 79278-71-0
1-phenethylpiperidin-4-one oxime

: 117523-68-9
Furan-3-carboxylic acid (1-phenethyl-piperidin-4-yl)-pyrazin-2-yl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: 44 percent / Cu powder / 6 h / 170 - 180 °C

3: 55 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; copper; triethylamine; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00123a028