488-93-7 Usage
Description
3-Furoic acid, also known as 3-carboxyfuran or 3-furoate, belongs to the class of organic compounds known as furoic acids. These are organic compounds containing a furoic acid moiety, with a structure characterized by a furan ring bearing a carboxylic acid group at the C2 or C3 carbon atom. 3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. It is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.
Chemical Properties
white to light yellow crystal powde
Uses
Different sources of media describe the Uses of 488-93-7 differently. You can refer to the following data:
1. 3-Furoic acid can be used as a reactant to synthesize:Furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction.(±)-Hyperolactone A by reacting with 2-methylbutanal.Furo[2,3-b]pyridin-4-one-5-carboxylate ester derivatives as potential non-nucleoside inhibitors of human herpesvirus polymerases.
2. 3-Furoic acid is used in synthesis of furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. It exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.
3. 3-Furoic acid can be used as a reactant to synthesize: Furan-2,5- and furan-2,4-dicarboxylic acid under solvent-free conditions via disproportionation reaction. (±)-Hyperolactone A by reacting with 2-methylbutanal.Furo[2,3-b]pyridin-4-one-5-carboxylate ester derivatives as potential non-nucleoside inhibitors of human herpesvirus polymerases.
Definition
ChEBI: A furoic acid carrying the carboxy group at position 3.
Synthesis Reference(s)
Tetrahedron Letters, 26, p. 1509, 1985 DOI: 10.1016/S0040-4039(00)98538-1
Biological Activity
3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.
Biochem/physiol Actions
3-Furoic acid exhibits hypolipidemic activity in rodents. It lowers serum cholesterol and serum triglyceride levels in mice and rats.
Purification Methods
Crystallise the acid from water or aqueous EtOH, and sublime it in a vacuum. [Beilstein 18 I 439, 18 III/IV 4052, 18/6 V 196.]
Check Digit Verification of cas no
The CAS Registry Mumber 488-93-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 488-93:
(5*4)+(4*8)+(3*8)+(2*9)+(1*3)=97
97 % 10 = 7
So 488-93-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H4O3/c6-5(7)4-1-2-8-3-4/h1-3H,(H,6,7)/p-1
488-93-7Relevant articles and documents
GAS-PHASE PYROLYTIC REACTIONS. PART 4. ARRHENIUS PARAMETERS AND HAMMETT ρ CONSTANTS IN GAS-PHASE ELIMINATIONS OF ALKYL PYRIDYL-, FURYL-, AND THIENYLCARBOXYLATE ESTERS
Al-Awadi, Nouria A.,Al-Bashir, Rasha F.,ElDusouqui, Osman M. E.
, p. 2911 - 2916 (1990)
The first-order rate coefficients ( 105k/s-1) of the gas-phase pyrolytic reactions of seven isopropyl (hetero)arylcarboxylate esters were calculated for 600 K to be: 75.34 for benzoate, and 100.0, 70.46, 94.03, 65.58, 100.9 and 120.2 for 2-thienyl-, 3-thienyl-, 2-furyl-, 3-furyl-, 3-pyridyl- and 4-pyridylcarboxylate, respectively.The corresponding Hammett replacement ρ0 substituent constants of the heterocyclic groups are: 0.53, -0.13, 0.42, -0.26, 0.55 and 0.88, respectively.The reported ρ0 constants are in agreement with other gas-phase and solution data, and are amenable to rationalization in terms of normal electronic and structural effects.Further, the physical constants of four new isopropyl heteroarylcarboxylate esters are described.
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Deady,Shanks
, p. 571 (1972)
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Reichstein,Zschokke
, p. 268,273 (1932)
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Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer
Tan, Wen-Yun,Lu, Yi,Zhao, Jing-Feng,Chen, Wen,Zhang, Hongbin
supporting information, p. 6648 - 6653 (2021/09/08)
The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
Electrophilicity and nucleophilicity of commonly used aldehydes
Pratihar, Sanjay
, p. 5781 - 5788 (2014/07/22)
The present approach for determining the electrophilicity (E) and nucleophilicity (N) of aldehydes includes a kinetic study of KMNO4 oxidation and NaBH4 reduction of aldehydes. A transition state analysis of the KMNO4 promoted aldehyde oxidation reaction has been performed, which shows a very good correlation with experimental results. The validity of the experimental method has been tested using the experimental activation parameters of the two reactions. The utility of the present approach is further demonstrated by the theoretical versus experimental relationship, which provides easy access to E and N values for various aldehydes and offers an at-a-glance assessment of the chemical reactivity of aldehydes in various reactions. the Partner Organisations 2014.
