2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal

Base Information

• Chemical Name: 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal
• CAS No.: 8545-55-9
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 8545-55-9.mol

Synonyms:2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal

Chemical Property of 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal

Chemical Property:

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Technology Process of 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal

There total 1 articles about 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6,6-dimethyl-4,8-dioxaspiro[2,5]oct-1-ene (60935-22-0) + phenylmagnesium bromide → 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal (8545-55-9)

Guidance literature:

With iron(III) chloride; In tetrahydrofuran; at -45 ℃; for 4h;

DOI:10.1016/S0022-328X(01)00679-9

Reference yield: 84.0%

acetic acid (64-19-7,77671-22-8) + 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal (8545-55-9) → (E)-3-Phenyl-acrylic acid 3-hydroxy-2,2-dimethyl-propyl ester + 3-hydroxy-2,2-dimethylpropyl 3-acetoxy-3-phenylpropanoate

Guidance literature:

With lead dioxide; at 25 ℃; for 6h;

DOI:10.1016/S0022-328X(01)00679-9

Reference yield: 83.0%

ethanol (64-17-5) + 2-phenylcyclopropanone 1,3-(2,2-dimethyl)propanediyl acetal (8545-55-9) → (E)-3-Phenyl-acrylic acid 3-hydroxy-2,2-dimethyl-propyl ester + 3-hydroxy-2,2-dimethylpropyl 3-ethoxy-3-phenylpropanoate

Guidance literature:

With trifluorormethanesulfonic acid; lead dioxide; at 25 ℃;

DOI:10.1016/S0022-328X(01)00679-9

upstream raw materials:

6,6-dimethyl-4,8-dioxaspiro[2,5]oct-1-ene