1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

Base Information

Chemical Name:1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one
CAS No.:1430091-15-8
Molecular Formula:C₂₁H₂₇N₃OS
Molecular Weight:369.531
Hs Code.:

Synonyms:1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

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Chemical Property of 1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

Chemical Property:

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Technology Process of 1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

There total 8 articles about 1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45534-10-9
2-ethenyl-4-methyl-1,3-thiazole

: 1430092-02-6
1-[2-(2-{(methoxymethyl)[(trimethylsilyl)methyl]amino}ethyl)phenyl]piperidin-2-one

: 1430091-15-8
1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 5339-85-5
2-aminophenethyl alcohol

: 1430091-15-8
1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 2 h / 85 °C / Inert atmosphere

5.1: potassium carbonate / water / 2 h / -10 - 0 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With dmap; potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 1430091-15-8
1-(2-{2-[3-(4-methyl-1,3-thiazol-2-yl)pyrrolidin-1-yl]ethyl}phenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 2 h / 85 °C / Inert atmosphere

5.1: potassium carbonate / water / 2 h / -10 - 0 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With dmap; potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;